Citation Information :
Gayas Z, Azher U, Paul ST, Reddy D. Comparative Evaluation of Influence of Self-assembling Peptide P11-4 Based Remineralization Agent on Incipient Dental Caries Lesions of Primary Teeth: A Polarized Light Microscopic Study. J South Asian Assoc Pediatr Dent 2023; 6 (1):3-8.
Background: Interception of the progression of incipient dental caries lesions with remineralization agents can facilitate their regression noninvasively.
Aim: To evaluate the influence of self-assembling peptide P11-4 (oligopeptide 104) based remineralization agent in comparison to fluoride-enhanced hydroxyapatite gel on incipient caries lesions in primary teeth.
Materials and methods: A total of 36 sound deciduous molars were selected and coated with two layers of acid-resistant varnish, leaving two windows (2 × 2 mm) on the buccal surface. The teeth were immersed in the demineralizing solution and incubated at 37°C for 4 days to produce artificial enamel caries lesions. One of the windows was assigned as a baseline lesion, while the other was designated as an experimental lesion and exposed to the test product and pH cycling. The samples were divided into three groups (n = 12). Group I—self-assembling peptide P11-4 gel, group II—fluoride-enhanced hydroxyapatite gel, and group III—control. The self-assembling peptide P11-4 and fluoride-enhanced hydroxyapatite were applied to the specimens for 5–3 minutes, respectively. The specimens were subjected to a 7-day pH-cycling regimen, followed by sectioning and examination under a polarized light microscope.
Results: The remineralization agents demonstrated a decrease in mean lesion depth in comparison to baseline, with the group I demonstrating greater reduction (165.235 ± 7.569–107.704 ± 6.735 μm) in comparison to group II (175.365 ± 12.238–127.462 ± 7.111 μm).
Conclusion: The self-assembling peptide P11-4 and fluoride-enhanced hydroxyapatite gel exhibited significant potential in the remineralization of artificial enamel caries lesions in primary teeth. However, the self-assembling peptide P11-4 demonstrated greater remineralization potential.
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