Journal of South Asian Association of Pediatric Dentistry

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VOLUME 5 , ISSUE 2 ( May-August, 2022 ) > List of Articles


Caries Inhibition Potential of Salivarius M18 Probiotic in High-risk Children

Siragam Pavani Lakshmi, Suzan Sahana, Aron Arun Kumar Vasa, Done Vasanthi

Keywords : Dental caries, Probiotics, Streptococcus mutans, Streptococcus salivarius M18

Citation Information : Lakshmi SP, Sahana S, Vasa AA, Vasanthi D. Caries Inhibition Potential of Salivarius M18 Probiotic in High-risk Children. J South Asian Assoc Pediatr Dent 2022; 5 (2):64-69.

DOI: 10.5005/jp-journals-10077-3227

License: CC BY-NC 4.0

Published Online: 23-08-2022

Copyright Statement:  Copyright © 2022; The Author(s).


Background: Preventive interventions that aim to halt or slow caries progression provides a practical solution for minimizing the problems stemming from caries. From the oral health perspective, the probiotic approach has been a popular method for modulating microbial communities. Aims: To evaluate the effect of Streptococcus salivarius M18 (Salivarius M18) probiotic in reducing plaque formation and lowering Streptococcus mutans counts when given as a daily supplement to children with high caries risk. Settings and design: A total of 60 children in the age-group of 6–12 years and those classified as “high risk” for caries on the basis of caries management by risk assessment (CAMBRA) were included. Materials and methods: Among the study participants, 30 were supplemented daily for 90 days with Salivarius M18 probiotic, and the remaining 30 served as untreated controls. All participants were subjected to evaluation of various parameters at baseline and 90 days following intervention. This included the decayed, missing, and filled teeth (DMFT)/dmft index, plaque index (Silness and Loe, 1964), and salivary S. mutans count (CFU/mL). The obtained data were compared with baseline scores; intergroup comparisons were made and subjected to statistical analysis. Statistical analysis: Wilcoxon's signed-rank test and Mann–Whitney U test were used for intra- and intergroup comparisons. Results and conclusion: Intergroup comparison showed statistically highly significant difference with respect to S. mutans counts and plaque scores. The Salivarius M18 probiotic can be recommended as a means of caries preventive intervention for children at high risk.

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